Life of Brain (blood barrier, that is)

(This is a repost of an article written by Khaly Castle with Erik Johnson, and originally published on 10/6/2012 at Blog)

Some things in life are bad.  They can really make you mad.
Other things just make you swear and curse.
When you’re chewing on life’s gristle, Don’t grumble, give a whistle.
And this’ll help things turn out for the best…Eric Idle, Monty Python’s Life Of Brian

The blood-brain barrier (BBB) is a highly effective biological mechanism, a metabolic and cellular barrier located in the capillaries of the brain.  Its primary function is to prevent the passage of nonessential molecules from the bloodstream to the neural tissue while allowing other substances through.

Delivery of medications and chemical treatments directly to the brain has been a holy grail of science.   The hindrance has, of course, been the BBB.  Nanotechnology is enabling remarkable strides in this field, allowing us to explore the possibilities of nano-induced medication transport, nano-enhanced visual imaging of brain tumors, nanorebooting of blood flow after brain injury, and more.  The emerging field that involves interaction between nanomaterials and living systems is known as “bionanointeraction”.

We know that the high surface energy of nanoparticles is an attractant for VOCs (volatile organic compounds).

This is the trick that is being capitalized upon by science to transport medicines to the brain…use of the surface excitability of nanoparticles to “glom onto” other substances and carry them into the target area.

This is a really good, basic, and graphic little video of how the surface excitability of nanoparticles works:

We know that mold can biosynthesize nanoparticles.

In one of our previous blog pieces, “And now for something completely different!”, we discussed mold and its ability to produce nanoparticles.

In nanotechnology, it has been discovered that by using the natural processes of biological systems, Aspergillus fumigatus can be used as a nanoparticle factory. The synthesis process was quite fast and silver nanoparticles were formed within minutes of silver ion coming in contact with the cell filtrate, claims the Bhainsha study from 2006, Extracellular biosynthesis of silver nanoparticles using the fungus Aspergillus fumigatus

If mold is in fact capable of biosynthesizing nanoparticles and metabolizing them, then that compounds things even more. We know mold is capable of biosynthesis, because scientists are using that technology to create “nanofactories”. There’s no reason to think mold would only do this in captivity.

We know that in this day and age, mold has a lot more access to metal particles than it used to.

Heavy metal contamination from burning oil, aerosolized household chemicals and pesticides, heavy metals and inorganic ions in our waste material which becomes processed into fertilizer via sewer sludge, industrial off-gassing…all have contributed to a toxic planet.

All of these things come into play in order to conceptualize this:

What if mold has adapted?   What if it is evolving to meet its survival needs in the industrial atmosphere created by man’s machinations?  Fungi, after all, have been in the business of evolving for well over a billion years.  What if some molds have mutated to allow them to withstand formerly intolerable metal particulates, and convert them to nanoparticulates?

If you’re still with me so far, consider the following theorizations by Erik Johnson.   Based on the above, I found them to make perfect sense and to fit well with what my illness experience has been.

  1. If a mold only produced nnps while obtaining metal particles, this could account for how the illnesses can mysteriously arise and disappear for “no reason”. Nanoparticle production would vary greatly.
  2. If the mold which produces the nnps is a toxin-producer, the attached VOC would be of the associated mycotoxin, or the toxin produced by that particular mold.
  3. But if the mold is NOT virulent, and just using Fentons (a bio-chemical process)to degrade materials… the resulting illness might be from whatever VOC was scrubbed from the air and transported into the brain instead of mycotoxins.

How would this manifest itself as illness expression?  Well, depending on the mold and what it came into contact with, there could be outbreaks of similar and yet slightly different illness.  According to Erik:

In hospitals, the nurses would have an inexplicable reaction to gluteraldehyde glommed onto the nnp.

In FEMA trailers, the “illness” would be the attached formaldehyde.

In Sheep Dip Farmers who get Myalgic Encephalomyelitis, it would be the OP pesticides they are using on moldy sheep.

In office buildings, reactions to the chemicals in carpet…. MCS galore!

More food for thought from Erik:

The common denominator between seemingly unrelated chemical exposures is that when mold is involved, novel pathogenesis is being seen.

In the past, mold did not have materials of such high density to process, so their Fentons would never have been so strong.

Which may account for the sporadic way this happened in the past, but has become quite common now.

The mold might sit there, toxic to bacteria, yet fairly benign against our normal human immunity, until metal particles sweep in on the winds, precipitate in the rain, channel to a mold colony, spew out nanoparticles, and suddenly turn the same mold colony into the “altered antigenic toxin spewing demon from Hell“, throwing out a means by which nearly any VOC that is there to be attracted by its surface energy, then suddenly allows these toxins to sail right on into the brain.

Stay tuned for the next installment.  Nature may have provided us with the means to perceive and identify this danger.